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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
28.79
Human Site:
Y154
Identified Species:
48.72
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
Y154
T
I
L
L
V
V
L
Y
K
Y
R
C
Y
K
V
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
T147
I
S
V
I
V
V
M
T
I
L
L
V
V
L
Y
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
L88
A
W
L
I
I
S
S
L
L
L
L
F
F
F
S
Dog
Lupus familis
XP_547503
717
78133
V370
P
V
T
L
C
M
I
V
V
V
A
T
I
K
S
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
Y154
T
I
L
L
V
V
L
Y
K
Y
R
C
Y
K
V
Rat
Rattus norvegicus
P97887
468
52771
Y154
T
I
L
L
V
V
L
Y
K
Y
R
C
Y
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
Y159
T
I
F
L
V
L
L
Y
K
Y
R
C
Y
K
F
Chicken
Gallus gallus
Q4JIM4
468
52812
Y155
T
I
L
L
V
V
L
Y
K
Y
R
C
Y
K
V
Frog
Xenopus laevis
O12976
433
48282
L137
G
W
L
I
I
S
S
L
L
L
L
F
F
F
S
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
W154
C
Y
K
V
I
Q
A
W
L
F
F
S
N
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
Y176
T
F
L
L
I
V
L
Y
K
K
R
C
Y
R
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
T148
L
L
L
F
L
F
T
T
I
Y
V
Q
E
V
L
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
Y187
T
I
F
L
V
V
L
Y
K
Y
R
C
Y
K
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
V154
F
A
G
G
I
P
I
V
L
R
Q
C
Y
M
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
13.3
6.6
13.3
N.A.
100
100
N.A.
80
100
6.6
0
N.A.
66.6
N.A.
13.3
93.3
P-Site Similarity:
100
33.3
26.6
33.3
N.A.
100
100
N.A.
86.6
100
26.6
33.3
N.A.
86.6
N.A.
33.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
8
0
0
0
8
0
0
0
0
% A
% Cys:
8
0
0
0
8
0
0
0
0
0
0
58
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% E
% Phe:
8
8
15
8
0
8
0
0
0
8
8
15
15
15
8
% F
% Gly:
8
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
43
0
22
36
0
15
0
15
0
0
0
8
0
8
% I
% Lys:
0
0
8
0
0
0
0
0
50
8
0
0
0
50
0
% K
% Leu:
8
8
58
58
8
8
50
15
29
22
22
0
0
15
15
% L
% Met:
0
0
0
0
0
8
8
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% N
% Pro:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
8
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
50
0
0
8
0
% R
% Ser:
0
8
0
0
0
15
15
0
0
0
0
8
0
0
22
% S
% Thr:
50
0
8
0
0
0
8
15
0
0
0
8
0
0
0
% T
% Val:
0
8
8
8
50
50
0
15
8
8
8
8
8
8
43
% V
% Trp:
0
15
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
50
0
50
0
0
58
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _